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KMID : 1128320110090010001
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Electrolytes & Blood Pressure
2011 Volume.9 No. 1 p.1 ~ p.6
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Vitamin D, and Kidney Disease
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Kim Hyung-Soo
Chung Woo-Kyung
Kim Se-Joong
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Abstract
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Mineral metabolism abnormalities, such as low 1,25-dihydroxyvitamin D (1,25(OH)2D) and elevated parathyroid hormone (PTH), are common at even higher glomerular filtration rate than previously described. Levels of 25-hydroxyvitamin D (25(OH)D) show an inverse correlation with those of intact PTH and phosphorus. Studies of the general population found much higher allcause and cardiovascular (CV) mortality for patients with lower levels of vitamin D; this finding suggests that low 25(OH)D level is a risk factor and predictive of CV events in patients without chronic kidney disease (CKD). 25(OH)D/1,25(OH)2D becomes deficient with progression of CKD. Additionally, studies of dialysis patients have found an association of vitamin D deficiency with increased mortality. Restoration of the physiology of vitamin D receptor activation should be essential therapy for CKD patients.
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KEYWORD
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renal insufficiency, chronic, vitamin D, deficiency
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